New triple negative breast cancer research recently published in the journal Cell appears to have identified a tumor suppressor gene involved in TNBC development and progression. In this new study, breast cancer researchers used a genetic screening process to examine gene changes in triple negative breast cancer cells. The investigators identified the gene PTPN12 as potent tumor suppressor gene that appears to be linked to TNBC. The researchers reported:
- The PTPN12 gene powerfully inhibits the growth of breast cells and their transformation into cancer cells.
- PTPN12 functions by blocking the action of multiple growth factor enzymes involved in breast cancer development and progression.
- The PTPN12 gene is frequently inactivated in triple negative breast cancer cells, thereby preventing it from blocking tumor suppression.
- Restoration of PTPN12 functionality inhibits the metastatic potential of TNBC cells.
- The tumorigenic and metastatic ability of TNBC cells can also be inhibited by blocking the growth factor enzymes normally blocked by the PTPN12 gene.
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